HLA-A*0201 | B2M | p53 (RMPEAAPPV)

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HLA-A*0201 | B2M | p53 (RMPEAAPPV)분자 배경

TP53 has been recognized as a tumor suppressor. 50% of cancers carry a TP53 mutation while many others affect other pathway components. High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells. The Human HLA-A*0201 p53 (GLAPPQHLIRV) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and GLAPPQHLIRV peptide of the p53.

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영어 이름연구 코드연구 개발 단계회사적응증임상 시험
RisuteganibALG-1001; AM011; AM-011(Allegro Ophthalmics)Phase 1 ClinicalAllegro Ophthalmics LlcDiabetic macular oedema; Geographic Atrophy; Macular Degeneration; Diabetic Retinopathy
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